After the destruction of Raccoon City in 2002, the T-virus quickly spread throughout the world. Both the United States, Europe, Asia, Africa, and Australia are all devastated to be dry and barren land. While all the inhabitants of the city turned into a zombie. Party Umbrella Corporation to try to stop the spread of this virus, but it is very difficult to do.
Alice, one of the creation of super Umbrella is now walking alone down a barren and dry desert. He knew that he was wanted by the Umbrella through satellite tracking. Dr. Isaac continued to try to find her, because Alice is the main key of making virus antivirus for menetralan influence-T.
Meanwhile, some members 'ex-Raccoon City' which selemat such as Carlos Olivera and LJ seemed to follow a convoy of some residents who survived, led by Claire Redfield.
While the convoy was checking a motel to find whether there are survivors, LJ bitten by a zombie. But he did not notify the head of the convoy.
In the morning, the team was surprised by the number of crows that tried to find prey. Carlos along with Claire led the team to save themselves. However, Nurse Betty and several people were killed in the attack was a crow. Not long ago, came to Alice. And with supernatural strength, he is killing a crow attack.
Alice then introduced himself to Claire and K-Mart. In other places, seems Dr. Isaacs with computer creations called the White Queen to see the way Alice via satellite. And Dr. Isaacs planned an attack against Alice when the time comes later.
Alice explains to Claire that the only safe place that still is Alaska. But apparently it takes to get there enough fuel, and fuel convoy team was owned by less. And they decided to look for fuel to the nearest big city is Las Vegas.
Dr. Isaac who already know that the team will go to Las Vegas immediately precedes and brings some vicious zombies to attack the convoy team. Arriving convoy team in Las Vegas, they immediately attacked by zombies. While L.J. that turned into a zombie and bites Carlos. Carlos finally shot dead L.J.
Meanwhile, Alice tried to shut down the computer by Dr. Isaace. But instead of destroyed satellites Umbrella. Alice then approached the tent where Dr.. Isaacs hiding and immediately eliminate all troops Umbrella. Dr. Isaacs who fear bolted using helicopters. But when Dr. Isaacs approached the helicopter, he was bitten by a zombie own luggage. Dr. Isaacs managed to escape, and Alice looked to shoot the helicopters are then undone because it was the only vehicle to Alaska.
Meanwhile in the Umbrella lab, Dr. Isaacs turned into a Tyrant and kill the rest of the lab. Dr. White Queen lock. Isaacs underground. On the surface, Carlos who is bitten looks vomiting, and told Alice that it was too late. Carlos then menrencanakan hara-kiri to facilitate the convoy approached the headquarters of the Umbrella team.
Alice with the team and then go after Carlos blow up the entrance. Alice asks Claire and K-Mart to immediately leave, while Alice's own entrance into the lab. He was surprised because the outside before he went into the lab, many clones of himself who had been murdered. In the lab she met with the White Queen and his computer explained that Dr. Isaacs has been turned into a monster. Alice then went into the underground lab. not much later, alice met kloningannya still in the process. clones are not perfect should therefore not be out first. but since that has become monstr dr.Isaacs tiba2 coming and surprisingly, it clones out of the glass and die.
At the bottom of the lab she met with Dr. Tyrant. Isaacs and fight until the end Dr. Isaacs was killed by a laser. alice in place pengecekkan clones. But before the same laser on Alice, who Alice cloning was still alive when exiting the first place to turn off the laser.
In Japan, the Japanese Umbrella decide all research will be continued at the headquarters of the Umbrella headquarters in Japan after the U.S. destroyed. But before they begin, Alice appeared via hologram and said he would chase them with my friends Alice.
The film ends with Alice and the clone which saw thousands of Alice clones in the same place.